Researchers believe they have recognized why a mutation in a particular gene can lead to fatness. In studies on mice which had been genetically modified to have the mutation, the mice consumed up to 80% more food than normal. According to Prof Baoji Xu If there is a difficulty with the BDNF gene, neurons can't talk to each other, and the leptin and insulin signals are unsuccessful, and appetite is not customized.
Many genes have been connected to obesity, one of them brain-derived neurotrophic factor gene has been shown to take part in a role in putting on heaviness in animal and some individual studies. The Georgetown University Medical Center researchers expect their conclusion could guide to novel ways to control heaviness.